Article

Caspase-Driven Microvascular Inflammation and Hypoperfusion in Intravascular Hemolysis: Roles of Leukocyte and Endothelial Activation

2025-03-13

Abstract excerpt

Intravascular hemolysis (IVH), a pathological process associated with various conditions, triggers vascular responses; however, the molecular and cellular mechanisms driving this process remain unclear. To explore the role of NLRP3 inflammasome- and caspase-dependent pathways in IVH-induced inflammation, we used in vivo models of acute and chronic IVH, alongside hemestimulation of endothelial cells, thereby isola...

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Literature Corpus work: 537a6e60-f844-583f-8336-29221618130b
DOI: 10.1101/2025.03.10.642471

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