Article

Influence of glutathione-S-transferase polymorphisms on the metabolism of the potent aromatase inhibitor, exemestane

2022-03-24

Abstract excerpt

<h4>Background: </h4> Exemestane (EXE) is used to treat post-menopausal women diagnosed with estrogen receptor positive (ER+) breast cancer. A major mode of metabolism of EXE and its active metabolite, 17β-dihydroexemestane (17β-DHE), is via glutathionylation by glutathione-S-transferase (GST) enzymes. The goal of the present study was to investigate the effects of genetic variation in EXE-metabolizing GST enzymes...

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Literature Corpus work: 53416fe6-32a7-5d65-a3d0-fe764bf301fd
DOI: 10.21203/rs.3.rs-1479213/v1

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