SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.

doi:10.1007/s10549-017-4243-3

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SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.

Breast cancer research and treatment - 1 Jul 2017

Dudenkov Tanda M, Ingle James N, Buzdar Aman U, Robson Mark E, Kubo Michiaki, Ibrahim-Zada Irada, Batzler Anthony, Jenkins Gregory D, Pietrzak Tracy L, Carlson Erin E, Barman Poulami, Goetz Matthew P, Northfelt Donald W, Moreno-Aspita Alvaro, Williard Clark V, Kalari Krishna R, Nakamura Yusuke, Wang Liewei, Weinshilboum Richard M

Abstract excerpt

BACKGROUND: Estrone (E1), the major circulating estrogen in postmenopausal women, promotes estrogen-receptor positive (ER+) breast tumor growth and proliferation. Two major reactions contribute to E1 plasma concentrations, aromatase (CYP19A1) catalyzed E1 synthesis from androstenedione and steroid sulfatase (STS) catalyzed hydrolysis of estrone conjugates (E1Cs). E1Cs have been associated with breast cancer risk...

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PMID: 28429243
DOI: 10.1007/s10549-017-4243-3
PMCID: PMC5600471

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