Article

Pancreatic cancer disrupts the adult hippocampal neurogenic niche

2026-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic cancer (PC) exhibits a striking association with depression, with neuropsychiatric symptoms frequently preceding diagnosis. However, the biological mechanisms linking pancreatic tumor development to central nervous system dysfunction remain poorly understood. Here, we investigated the impact of PC progression on adult hippocampal neurogenesis using complementary orthotopic xenograft a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5311c4f5-7069-582e-8ede-bbd34d595b8f
DOI: 10.64898/2026.07.03.736329

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 9 closest

Pancreatic cancer disrupts the adult hippocampal neurogenic nicheDOI 10.64898/2026.07.03.736329Read

Beta cells are essential drivers of pancreatic ductal adenocarcinoma developmentSemantic proximity Read

Targeting HDACs in Pancreatic Neuroendocrine Tumor ModelsSemantic proximity Read

Glial-Restricted Precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablationSemantic proximity Read

The Role of the Autonomic Nervous System in Oncogenesis: Friend or Foe?Semantic proximity Read

Distinct neuronal, proliferative, and secretory pathways are perturbed in cancer survivors with depressive symptomsSemantic proximity Read

Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancerSemantic proximity Read

Multiple cancer cell types release LIF and Gal3 to hijack neural signalsSemantic proximity Read

Adrenergic signaling induces a pro-tumorigenic B cell state in colorectal cancerSemantic proximity Read

Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesisSemantic proximity Read