Article

Adrenergic signaling induces a pro-tumorigenic B cell state in colorectal cancer

2026-01-23

Abstract excerpt

The importance of neuron-tumor crosstalk has gained increasing attention, yet its influence on the cellular and molecular landscape of colorectal cancer (CRC) remains largely unexplored. Here, we show that colonic innervation shapes the tumor immune microenvironment in a murine model of colitis-associated CRC. Although neuronal density does not affect tumor number, size, or overall burden, transcriptomic profiling...

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Literature Corpus work: a646e3b3-744d-5e6f-9232-724927081556
DOI: 10.64898/2026.01.23.700260

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