Article

Early Antibody-Mediated Immunity to Tuberculosis in Mice Requires NLRP3

2025-07-18

Abstract excerpt

While antibodies have emerged as potential mediators of protective immunity against Mycobacterium tuberculosis (Mtb), their mechanisms of action remain incompletely understood. Here, we demonstrate that immune complexes of Mtb and monoclonal antibodies targeting the Mtb phosphate transporter subunit PstS1 robustly activate the NLRP3 inflammasome in human and murine macrophages, leading to enhanced interleukin-1β...

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Identifiers and source

Literature Corpus work: 5308cf79-4071-5717-96c1-303796cfaa26
DOI: 10.1101/2025.07.18.665318

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