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Article

The real war on cancer: the evolutionary dynamics of cancer suppression

10 Oct 2012

Abstract excerpt

Cancer is a disease of multicellular animals caused by unregulated cell division. The prevailing model of cancer (multistage carcinogenesis) is based on the view that cancer results after a series of (generally somatic) mutations that knock out the genetic mechanisms suppressing unregulated cell growth. The chance of these mutations occurring increases with size and longevity, leading to Peto's paradox: why don't...

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PMID: 23396311
DOI: 10.1111/eva.12018

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