Article
Naturally occurring cancers in dogs: insights for translational genetics and medicine.
ILAR journal - 1 Jan 2014
Alvarez Carlos E
Abstract excerpt
Here, we briefly review the state of knowledge of human cancer genetics to elaborate on the need for different types of mammalian models, highlighting the strengths of the dog. Mouse models are unparalleled for their experimental tractability and rapid genetic manipulation but have some key limitations in the area of human relevance. Companion dog models are attractive, because they are genetically more similar...
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