Article

Dissecting HSV-1-induced host shut-off at RNA level

2020-05-20

Abstract excerpt

Herpes simplex virus 1 (HSV-1) installs a profound host shut-off during lytic infection. The virion host shut-off ( vhs ) protein plays a key role in this process by efficiently cleaving both host and viral mRNAs in a translation-initiation-dependent manner. Furthermore, the onset of viral DNA replication is accompanied by a rapid decline in transcriptional activity of the host genome. Both mechanisms have tremen...

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Literature Corpus work: 52fb4643-3450-502c-8cb0-5e7ca7dba5b7
DOI: 10.1101/2020.05.20.106039

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