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Article

Widespread disruption of host transcription termination in HSV-1 infection

20 May 2015

Abstract excerpt

Herpes simplex virus 1 (HSV-1) is an important human pathogen and a paradigm for virus-induced host shut-off. Here we show that global changes in transcription and RNA processing and their impact on translation can be analysed in a single experimental setting by applying 4sU-tagging of newly transcribed RNA and ribosome profiling to lytic HSV-1 infection. Unexpectedly, we find that HSV-1 triggers the disruption...

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PMID: 25989971
DOI: 10.1038/ncomms8126

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