Article

NAD <sup>+</sup> controls circadian rhythmicity during cardiac aging

2023-11-05

Abstract excerpt

Disruption of the circadian clock as well as reduced NAD + levels are both hallmarks of aging. While circadian rhythms and NAD + metabolism have been linked in heart disease, their relationship during cardiac aging is less clear. Here, we show that aging leads to disruption of diurnal gene expression in the heart. Long-term supplementation with the NAD + precursor nicotinamide riboside (NR) boosts NAD + levels...

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Literature Corpus work: 52dd9240-291f-584d-995c-b07a648550f4
DOI: 10.1101/2023.11.02.565150

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