Article

<i>De novo</i> assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptation

2019-09-02

Abstract excerpt

Structural variants (SVs) may play important roles in human adaption to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome (ZF1), with a contig N50 length of 24.57 mega-base pairs (Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps (0.25...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3bf46b3-a034-561a-b764-e458afd3dca5
DOI: 10.1101/753186

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>De novo</i> assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptationDOI 10.1101/753186Read

De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptationSemantic proximity Read

Tibetan near-complete pangenome reveals complex variants underlying high-altitude adaptationSemantic proximity Read

Structural variant selection for high-altitude adaptation using single-molecule long-read sequencingSemantic proximity Read

Characterization of Structural Variation in Tibetans Reveals New Evidence of High-altitude Adaptation and IntrogressionSemantic proximity Read

Whole genome re-sequencing identifies unique adaption of single nucleotide polymorphism, insertion/deletion and structure variation related to hypoxia in Tibetan chickens.Semantic proximity Read

Genetic analysis of cold tolerance and high-altitude adaptation in Gannan indigenous Tibetan sheep through genome-wide scans.Semantic proximity Read

Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation.Semantic proximity Read

Genomic insights into population structure, adaptation, and archaic introgression at the Himalayan-East Asian crossroads.Semantic proximity Read

Genomic insights into population stratification, biological adaptation, and archaic introgression at the crossroads of the Himalayas and lowland East AsiaSemantic proximity Read

GCH1 plays a role in the high-altitude adaptation of Tibetans.Semantic proximity Read

Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas.Semantic proximity Read

Genetic diversity and population structure of Tibetan sheep breeds determined by whole genome resequencing.Semantic proximity Read