Article

Selective Knockout of Murine Glutamic Acid-rich Protein 2 (GARP2) Significantly Alters Cellular Dark Noise in Rod Photoreceptors

2025-05-14

Abstract excerpt

GARP2, a glutamic-acid-rich protein found exclusively in rod photoreceptors, has been suggested to function as a structural protein, a modulator of the cGMP phosphodiesterase enzyme (PDE6), and a gating inhibitor of the rod cGMP-gated cation channel. GARP2 is a splice variant of the Cngb1 gene, which in the rods encodes the β-subunit of the cyclic nucleotide-gated cation channel. Mutations in Cngb1 cause retinit...

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Literature Corpus work: 52c19db0-0c28-5126-b56e-93ffd8ed429a
DOI: 10.1101/2025.05.09.653122

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