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Article

Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice

31 Mar 2020

Abstract excerpt

Variants in interphotoreceptor matrix proteoglycans (IMPG2) have been reported in retinitis pigmentosa (RP) and vitelliform macular dystrophy (VMD) patients. However, the underlying molecular mechanisms remain elusive due to a lack of suitable disease models. We developed two independent Impg2 knockout (KO) mouse models using the CRISPR/Cas9 technique to assess the in vivo functions of Impg2 in the retina. Impg2...

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PMID: 32242237
DOI: 10.1093/hmg/ddaa062

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Deletion of the Impg2 gene causes the degeneration of rod and cone cells in micePMID 32242237Read ↗

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