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Article

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Jan 2011

Michalakis Stylianos, Zong Xiangang, Becirovic Elvir, Hammelmann Verena, Wein Thomas, Wanner Klaus T, Biel Martin

Abstract excerpt

The cyclic nucleotide-gated (CNG) cation channel of rod photoreceptors is a heterotetramer consisting of homologous CNGA1 and CNGB1a subunits. While CNGA1 is indispensable for channel activation, the specific role of CNGB1a in this process has remained elusive. Here, we show that the N-terminal glutamic acid-rich protein (GARP) domain of CNGB1a and soluble GARP2, which corresponds to the proximal portion of the...

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Identifiers

PMID: 21209198
DOI: 10.1523/JNEUROSCI.4735-10.2011
PMCID: PMC6622767

Genes

CNGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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