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Article

Oxaliplatin induces different cellular and molecular chemoresistance patterns in colorectal cancer cell lines of identical origins.

BMC genomics - 16 Jul 2013

Virag Piroska, Fischer-Fodor Eva, Perde-Schrepler Maria, Brie Ioana, Tatomir Corina, Balacescu Loredana, Berindan-Neagoe Ioana, Victor Bogdan, Balacescu Ovidiu

Abstract excerpt

BACKGROUND: Cancer cells frequently adopt cellular and molecular alterations and acquire resistance to cytostatic drugs. Chemotherapy with oxaliplatin is among the leading treatments for colorectal cancer with a response rate of 50%, inducing intrastrand cross-links on the DNA. Despite of this drug's efficiency, resistance develops in nearly all metastatic patients. Chemoresistance being of crucial importance for...

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Identifiers

PMID: 23865481
DOI: 10.1186/1471-2164-14-480
PMCID: PMC3776436

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