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Article

The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.

Oncology research - 1 Sept 2020

Wei Wei, Ma Xiao-Dong, Jiang Guan-Min, Shi Bin, Zhong Wen, Sun Chun-Lei, Zhao Liang, Hou Yan-Jiao, Wang Hao

Abstract excerpt

Although oxaliplatin serves as one of the first-line drugs prescribed for treating colorectal cancer (CRC), the therapeutic effect is disappointing due to drug resistance. So far, the molecular mechanisms mediating oxaliplatin resistance remain unclear. In this study, we found the chemoresistance in oxaliplatin-resistant HCT116 cells (HCT116/OXA) was mediated by the upregulation of ERCC1 expression. In addition,...

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Identifiers

PMID: 32331534
DOI: 10.3727/096504020X15877284857868
PMCID: PMC7851510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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