Article

SARS-CoV-2 immune complex triggers human monocyte necroptosis

2022-10-14

Abstract excerpt

We analyzed the ability of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) itself and SARS-CoV-2-IgG immune complexes to trigger human monocyte necroptosis. SARS-CoV-2 was able to induce monocyte necroptosis dependently of MLKL activation. Necroptosis-associated proteins (RIPK1, RIPK3 and MLKL) were involved in SARS-CoV-2 N1 gene expression in monocytes. SARS-CoV-2 immune complexes promoted monocyte n...

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Literature Corpus work: 527e36cd-f36f-5387-9a20-bdb9bc928859
DOI: 10.1101/2022.10.13.512127

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