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Article

Distinct regulation of dengue virus-induced inflammasome activation in humanmacrophage subsets

7 Jun 2013

Abstract excerpt

Macrophages (Mϕ) are the major source of inflammatory cytokines and are target cells for dengue virus (DV) replication. However, Mϕ are heterogeneous and their phenotypic and functional diversities are influenced by cytokines that regulate their differentiation, tissue distribution, and defense against invading pathogens. In vitro, human primary macrophages are derived from peripheral blood CD14+ monocytes in the...

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PMID: 23742038
DOI: 10.1186/1423-0127-20-36

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