Article

Naa10 regulates hippocampal neurite outgrowth <i>via</i> Btbd3 N-α-acetylation-mediated actin dynamics

2024-05-10

Abstract excerpt

Protein N-α-acetylation is widespread in eukaryotes, yet its neuronal role remains unclear. Mutations in human N-α-acetyltransferase 10 (NAA10) lead to developmental defects affecting brain function, such as intellectual disability and autism. We found that hippocampal CA1-specific Naa10 -knockout mice exhibit anxiety and reduced hippocampal dendritic complexity. Mechanistically, Naa10 promotes neurite outgrowth...

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Literature Corpus work: 5271c1d2-2139-510c-bc7c-d529d61dfe8c
DOI: 10.1101/2024.05.09.583166

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