Article

Molecular Basis for N-terminal Alpha-Synuclein Acetylation by Human NatB

2020-05-13

Abstract excerpt

NatB is one of three major N-terminal acetyltransferase (NAT) complexes (NatA-NatC), which co-translationally acetylate the N-termini of eukaryotic proteins. Its substrates account for about 21% of the human proteome, including well known proteins such as actin, tropomyosin, CDK2, and α-synuclein (αSyn). Human NatB (hNatB) mediated N-terminal acetylation of αSyn has been demonstrated to play key roles in Parkinson...

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Literature Corpus work: 370e9500-83d9-5643-a484-7c25a4baec79
DOI: 10.1101/2020.05.11.089318

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