Article

<i>PAX</i> fusion proteins deregulate gene networks controlling mitochondrial translation in pediatric rhabdomyosarcoma

2024-08-03

Abstract excerpt

Alveolar rhabdomyosarcoma (ARMS) patients harboring PAX3-FOXO1 and PAX7-FOXO1 fusion proteins exhibit a greater incidence of tumor relapse, metastasis, and poor survival outcome, thereby underscoring the urgent need to develop effective therapies to treat this subtype of childhood cancer. To uncover mechanisms that contribute to tumor initiation, we developed a novel muscle progenitor model and used epigenomic app...

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Literature Corpus work: b8ece919-d8e1-5be2-95bf-3ed08bbfe1ff
DOI: 10.1101/2024.07.31.606039

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