Article

Reprogramming Dedifferentiation Regulatory Networks Preserves Human Chondrocyte Phenotypes

2026-05-13

Abstract excerpt

Chondrocyte-based cartilage repair strategies such as autologous chondrocyte implantation (ACI) require extensive in vitro expansion to obtain clinically relevant cell numbers. However, this expansion step progressively drives chondrocyte dedifferentiation, reducing matrix-forming capacity and contributing to variable repair outcomes. To better understand this process, we used single-nucleus multiome profiling (sn...

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Literature Corpus work: 52675603-da53-572a-8af6-ed6bd461b69b
DOI: 10.64898/2026.05.10.724134

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