Article

ATGL-mediated lipolysis is essential for myocellular mitochondrial function and augments PPARδ-induced improvements in mitochondrial respiration

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Defects in ATGL-mediated myocellular LD lipolysis results in mitochondrial dysfunction of unknown origin, which can be rescued by PPAR agonists. Here we examine whether ATGL-mediated lipolysis is required to maintain mitochondrial network connectivity and function. Moreover, we explored if the functional implications of ATGL deficiency for mitochondrial network dynamics and function can be allev...

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Literature Corpus work: 52606177-7e51-5a37-bc1f-cfa7204b4558
DOI: 10.1101/2024.10.31.621255

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