Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts.

Biochimica et biophysica acta - 1 Dec 2013

Michot Caroline, Mamoune Asmaa, Vamecq Joseph, Viou Mai Thao, Hsieh Lu-Sheng, Testet Eric, Lainé Jeanne, Hubert Laurence, Dessein Anne-Frédérique, Fontaine Monique, Ottolenghi Chris, Fouillen Laetitia, Nadra Karim, Blanc Etienne, Bastin Jean, Candon Sophie, Pende Mario, Munnich Arnold, Smahi Asma, Djouadi Fatima, Carman George M, Romero Norma, de Keyzer Yves, de Lonlay Pascale

Abstract excerpt

Lipin-1 deficiency is associated with massive rhabdomyolysis episodes in humans, precipitated by febrile illnesses. Despite well-known roles of lipin-1 in lipid biosynthesis and transcriptional regulation, the pathogenic mechanisms leading to rhabdomyolysis remain unknown. Here we show that primary myoblasts from lipin-1-deficient patients exhibit a dramatic decrease in LPIN1 expression and phosphatidic acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation Mediators

Share to Lipids

Share to Muscle Fibers, Skeletal

Share to Myoblasts

Share to Pancreatitis-Associated Proteins

Share to Phosphatidate Phosphatase

Share to Rhabdomyolysis

Source

Open in PubMed Open full text

Identifiers

PMID: 23928362
DOI: 10.1016/j.bbadis.2013.07.021
PMCID: PMC4007099

Genes

ACACB
LPIN1
ACADVL
CPT2
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts.PMID 23928362Read ↗

Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone‐responsive myopathySemantic proximity Read ↗

Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations.Semantic proximity Read ↗

The lipin family: mutations and metabolism.Semantic proximity Read ↗

Lipid mediated ER-stress contributes to the pathogenesis of mitochondrial myopathiesSemantic proximity Read ↗

Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.Semantic proximity Read ↗

Lipolysis and lipophagy in lipid storage myopathiesSemantic proximity Read ↗

Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long-chain fatty acid oxidation disorders.Semantic proximity Read ↗

Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects.Semantic proximity Read ↗

Transcriptional regulation profiling reveals PPARA-mediated fatty acid oxidation as a novel therapeutic target in phospholamban R14del cardiomyopathySemantic proximity Read ↗

Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.Semantic proximity Read ↗

[Rhabdomyolysis in carnitine palmitoyltransferase II deficiency: developments in pathophysiology, diagnosis and therapy].Semantic proximity Read ↗

A Multi-target Pharmacological Correction of a Lipoyltransferase LIPT1 Gene Mutation in Patient-Derived Cellular ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.