Article

Skeletal muscle biomarkers of amyotrophic lateral sclerosis: a large-scale, multi-cohort proteomic study

2025-04-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Biomarkers with clear contexts-of-use are important tools for ALS therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response. To this end, we undertook a large-scale proteomic study in well-phenotyped cohorts to identify biomarker candidates of ALS disease state and disease prog...

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Literature Corpus work: fa186ed9-7bee-5655-b645-3cc7d32c06ad
DOI: 10.1101/2025.04.23.25326161

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