Article

Reduced B cell activation in Germinal center reaction of the mouse model of Li-Fraumeni syndrome

2026-01-23

Abstract excerpt

The TP53 mutation associated with Li-Fraumeni syndrome in humans is known to exhibit p53 gain-of-function properties leading to early cancer onset. To explore whether these patients also have compromised immune responses due to p53 mutations, we investigated the humoral immune response using a Li-Fraumeni mouse model harboring a structural mutation, Trp53R172H (equivalent to codon 175 in humans). Trp53R172H mic...

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Literature Corpus work: 52528f67-4b9b-56aa-a9cf-3599edb1156a
DOI: 10.64898/2026.01.21.700937

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