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Article

Role of p53 in Systemic Autoimmune Diseases

1 Jan 2014

Abstract excerpt

The tumor suppressor p53 has been shown to play a central role in tumor suppression by inducing apoptosis, cell cycle arrest, senescence, and DNA repair. In addition, recent observations indicate that the dysfunction of p53 is associated with the development of autoimmune diseases. In this review, we discuss the importance of p53 in various human and murine autoimmune diseases. We also discuss the role of p53 in...

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PMID: 25597313
DOI: 10.1615/critrevimmunol.2014012193

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