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L-Ascorbic acid preferentially kills KRAS mutant pancreatic cancer cells through DNA damage

2 Jul 2025

Abstract excerpt

Pancreatic cancer (PC) is a worldwide leading cause of cancer-related death. Despite recent progress using immunotherapy with checkpoint inhibitors or targeted agents in various solid tumors, these approaches have not been successful in PC. Therefore, there is an urgent unmet need for the development of novel therapeutics for these difficult-to-treat patients. We hypothesized that high-dose L-ascorbic acid (AA)...

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PMID: 40595145
DOI: 10.1038/s41598-025-07668-1

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