Article

Identifying simultaneous inhibition of riboflavin metabolism and MEK as a novel therapeutic strategy for pancreatic cancer

2024-10-26

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains a formidable challenge with a survival rate of approximately 10%, largely due to the lack of diagnostic and therapeutic options. To identify novel therapeutic targets for PDAC, we previously developed a Drosophila melanogaster model, the ’ 4-hit ’ fly, which mimics the alterations in KRAS , TP53 , CDKN2A , and SMAD4 genes observed in PDAC. Through whole-body ge...

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Literature Corpus work: 9beee056-4e37-518d-a661-1d386bd7dfc1
DOI: 10.1101/2024.10.23.619807

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