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High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy

13 Jan 2011

Abstract excerpt

Resistance to tamoxifen in breast cancer patients is a serious therapeutic problem and major efforts are underway to understand underlying mechanisms. Resistance can be either intrinsic or acquired. We derived a series of subcloned MCF7 cell lines that were either highly sensitive or naturally resistant to tamoxifen and studied the factors that lead to drug resistance. Gene-expression studies revealed a signature...

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PMID: 21233418
DOI: 10.1073/pnas.1018157108

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