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Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injury

3 Dec 2024

Abstract excerpt

The immune system coordinates the response to cardiac injury and controls regenerative and fibrotic scar outcomes in the heart and subsequent chronic low-grade inflammation associated with heart failure. Adult mice and humans lack the ability to fully recover while adult zebrafish spontaneously regenerate after heart injury. Here we profile the inflammatory response to heart cryoinjury in zebrafish and coronary...

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PMID: 39627536
DOI: 10.1038/s42003-024-07315-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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