Article

Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis

2001-12-17

Abstract excerpt

Nek2 is a cell-cycle-regulated protein kinase that localizes to the centrosome and is likely to be involved in regulating centrosome structure at the G2/M transition. Here, we localize the functional human Nek2 gene to chromosome 1 and show that alternative polyadenylation signals provide a mechanism for generating two distinct isoforms. Sequencing of products generated by reverse transcriptase PCR, immunoblotting...

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Literature Corpus work: 521ba099-1e73-5ad5-943f-8e9c31c64db2
DOI: 10.1042/bj3610077

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