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Article

Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas

14 Oct 2008

Abstract excerpt

Protein kinases that regulate the centrosome cycle are often aberrantly controlled in neoplastic cells. Changes in their expression or activity can lead to perturbations in centrosome duplication, potentially leading to chromosome segregation errors and aneuploidy. Testicular germ cell tumours (TGCTs) are characterized by amplification of centrosomes through unknown mechanisms. Herein, we report that Nek2, a...

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PMID: 19023884
DOI: 10.1002/path.2471

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