Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-Related Decrease of Meiotic Cohesins in Human Oocytes

7 May 2014

Abstract excerpt

Aneuploidy in fetal chromosomes is one of the causes of pregnancy loss and of congenital birth defects. It is known that the frequency of oocyte aneuploidy increases with the human maternal age. Recent data have highlighted the contribution of cohesin complexes in the correct segregation of meiotic chromosomes. In mammalian oocytes, cohesion is established during the fetal stages and meiosis-specific cohesin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomic variations and chromosomal abnormalities
Share to Genomics and Chromatin Dynamics
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24806359
DOI: 10.1371/journal.pone.0096710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-Related Decrease of Meiotic Cohesins in Human OocytesPMID 24806359Read ↗

Age-Dependent Susceptibility of Chromosome Cohesion to Premature Separase Activation in Mouse Oocytes1Semantic proximity Read ↗

Ovulation suppression protects against chromosomal abnormalities in mouse eggs at advanced maternal ageSemantic proximity Read ↗

Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errorsSemantic proximity Read ↗

Chromosome Ageing Occurs at the Primordial Follicle Stage in both Mouse and Human OocytesSemantic proximity Read ↗

Meiotic Cohesin and Variants Associated With Human Reproductive Aging and DiseaseSemantic proximity Read ↗

Meiotic Origins of Maternal Age-Related Aneuploidy1Semantic proximity Read ↗

Chromosome Cohesion Established by Rec8-Cohesin in Fetal Oocytes Is Maintained without Detectable Turnover in Oocytes Arrested for Months in MiceSemantic proximity Read ↗

Age-dependent loss of cohesion protection in human oocytesSemantic proximity Read ↗

Chromosome cohesion decreases in human eggs with advanced maternal ageSemantic proximity Read ↗

Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced.Semantic proximity Read ↗

Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase BSemantic proximity Read ↗

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.