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Article

Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2006

Vyhlidal Carrie A, Gaedigk Roger, Leeder J Steven

Abstract excerpt

The mechanisms underlying interindividual variation and developmental changes in cytochrome P450 3A (CYP3A) expression and activity are not fully understood. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) methods were used to detect, during human fetal and pediatric development, mRNA expression of nuclear receptors involved in the regulation of CYP3A genes. Quantitative RT-PCR was conducted...

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Identifiers

PMID: 16243958
DOI: 10.1124/dmd.105.005967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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