Article

First gene-edited calf with reduced susceptibility to a major viral pathogen

2022-12-08

Abstract excerpt

Bovine viral diarrhea virus (BVDV) is one of the most important viruses affecting the health and well-being of bovine species throughout the world. Here we used CRISPR-mediated homology-directed repair and somatic cell nuclear transfer to produce a live calf with a six amino acid substitution in the BVDV binding domain of bovine CD46. The result was a gene-edited calf with dramatically reduced susceptibility to in...

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Literature Corpus work: 51f8e488-c41a-5c3d-93f1-7a638650b332
DOI: 10.1101/2022.12.08.519336

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