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Article

The genomes of precision edited cloned calves show no evidence for off-target events or increased de novo mutagenesis.

BMC genomics - 17 Jun 2021

Jivanji Swati, Harland Chad, Cole Sally, Brophy Brigid, Garrick Dorian, Snell Russell, Littlejohn Mathew, Laible Götz

Abstract excerpt

BACKGROUND: Animal health and welfare are at the forefront of public concern and the agricultural sector is responding by prioritising the selection of welfare-relevant traits in their breeding schemes. In some cases, welfare-enhancing traits such as horn-status (i.e., polled) or diluted coat colour, which could enhance heat tolerance, may not segregate in breeds of primary interest, highlighting gene-editing...

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Identifiers

PMID: 34139989
DOI: 10.1186/s12864-021-07804-x
PMCID: PMC8212539

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