Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fertility and early embryonic development in a CD46-edited Gir heifer with reduced susceptibility to BVDV†.

Biology of reproduction - 14 Feb 2025

Snider Alexandria P, Workman Aspen M, Heaton Michael P, Vander Ley Brian L, Krueger Alexandria C, Sonstegard Tad S

Abstract excerpt

Bovine viral diarrhea virus (BVDV) infection during pregnancy is a significant contributor to reproductive failures in cattle. The bovine receptor for BVDV (CD46) was previously edited with a six amino acid substitution (G82QVLAL to A82LPTFS) and shown to have significantly reduced BVDV susceptibility in a Gir heifer calf. Since a role for CD46 has been proposed in mammalian fertilization, our objective was to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Membrane Cofactor Protein
Share to Bovine Virus Diarrhea-Mucosal Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cattle

Share to Diarrhea Viruses, Bovine Viral

Share to Embryonic Development

Share to Fertility

Share to Gene Editing

Share to Pregnancy

Source

Identifiers

PMID: 39561121
DOI: 10.1093/biolre/ioae169

Genes

CD46

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Fertility and early embryonic development in a CD46-edited Gir heifer with reduced susceptibility to BVDV†.PMID 39561121Read ↗

First gene-edited calf with reduced susceptibility to a major viral pathogenSemantic proximity Read ↗

A Nonsense Mutation in TMEM95 Encoding a Nondescript Transmembrane Protein Causes Idiopathic Male Subfertility in CattleSemantic proximity Read ↗

Soluble forms of CD46 are detected in Bos taurus plasma and neutralize BVDV, the bovine pestivirus.Semantic proximity Read ↗

Vaccination against foot-and-mouth disease (FMD) deteriorates sperm quality for a substantial duration post-vaccination and alters the abundance of fertility-related mRNA transcripts in Murrah Buffalo bulls spermatozoaSemantic proximity Read ↗

SMAD6 inhibits granulosa cell proliferation and follicle growth rate in carrier and noncarrier heifers of the Trio allele.Semantic proximity Read ↗

CD46 (membrane cofactor protein of complement, measles virus receptor): structural and functional divergence among species (review).Semantic proximity Read ↗

Subfertility in bulls carrying a nonsense mutation in transmembrane protein 95 is due to failure to interact with the oocyte vestments.Semantic proximity Read ↗

Genome-wide association analyses in dairy heifers highlight genes overlapping with mouse and human fertility and human health traitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.