Article

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.

2021-07-27

Abstract excerpt

<title>Abstract</title> <p>We investigated global patterns of genetic variation and signatures of natural selection at host genes relevant to SARS-CoV-2 infection (<italic>ACE2, TMPRSS2, DPP4</italic>, and <italic>LY6E</italic>). We analyzed novel data from 2,012 ethnically diverse Africans and 15,997 individuals of European and African ancestry with electronic health records, and integrated with global data from...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51d63aec-28a5-5dd6-887f-2dcfdb61117e
DOI: 10.21203/rs.3.rs-673011/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.DOI 10.21203/rs.3.rs-673011/v1Read

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infectionSemantic proximity Read

Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection.Semantic proximity Read

Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infectionSemantic proximity Read

Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection.Semantic proximity Read

Population history and natural selection shape patterns of genetic variation in 132 genes.Semantic proximity Read

Genetic variation and adaptation in Africa: implications for human evolution and disease.Semantic proximity Read

Signals of recent positive selection in a worldwide sample of human populations.Semantic proximity Read

Searching for signals of evolutionary selection in 168 genes related to immune function.Semantic proximity Read

Genetic variation and recent positive selection in worldwide human populations: evidence from nearly 1 million SNPs.Semantic proximity Read

Lineage-specific positive selection on ACE2 contributes to the genetic susceptibility of COVID-19Semantic proximity Read

Selected neuropeptide genes show genetic differentiation between Africans and non-Africans.Semantic proximity Read

Architecture of polymorphisms in the human genome reveals functionally important and positively selected variants in immune response and drug transporter genes.Semantic proximity Read