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Article

Lineage-specific positive selection on ACE2 contributes to the genetic susceptibility of COVID-19

1 Jul 2022

Abstract excerpt

Abstract The Angiotensin-Converting Enzyme-2 (ACE2) gene, located on Xp22.2, attracts a great deal of attention because the protein it encodes is believed to be the functional cellular receptor for the new coronavirus (SARS-CoV-2). However, recent studies are controversial, especially concerning the intrinsic link between ACE2 diversity and COVID-19 susceptibility. Here, we conduct a population genetic study on...

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PMID: 36199986
DOI: 10.1093/nsr/nwac118

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