Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection.

doi:10.1073/pnas.2123000119

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2022

Zhang Chao, Verma Anurag, Feng Yuanqing, Melo Marcelo C R, McQuillan Michael, Hansen Matthew, Lucas Anastasia, Park Joseph, Ranciaro Alessia, Thompson Simon, Rubel Meagan A, Campbell Michael C, Beggs William, Hirbo Jibril, Wata Mpoloka Sununguko, George Mokone Gaonyadiwe, Nyambo Thomas, Wolde Meskel Dawit, Belay Gurja, Fokunang Charles, Njamnshi Alfred K, Omar Sabah A, Williams Scott M, Rader Daniel J, Ritchie Marylyn D, de la Fuente-Nunez Cesar, Sirugo Giorgio, Tishkoff Sarah A

Abstract excerpt

Human genomic diversity has been shaped by both ancient and ongoing challenges from viruses. The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a devastating impact on population health. However, genetic diversity and evolutionary forces impacting host genes related to SARS-CoV-2 infection are not well understood. We investigated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Angiotensin-Converting Enzyme 2

Share to COVID-19

Share to Genetic Variation

Share to Phenotype

Share to SARS-CoV-2

Share to SARS-CoV-2 and COVID-19 Research

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 35580180
DOI: 10.1073/pnas.2123000119
PMCID: PMC9173769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection.PMID 35580180Read ↗

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infectionSemantic proximity Read ↗

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.Semantic proximity Read ↗

Genetic variation analyses indicate conserved SARS-CoV-2-host interaction and varied genetic adaptation in immune response factors in modern human evolution.Semantic proximity Read ↗

Genetic variations in the human severe acute respiratory syndrome coronavirus receptor ACE2 and serine protease TMPRSS2.Semantic proximity Read ↗

Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infectionSemantic proximity Read ↗

Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection.Semantic proximity Read ↗

Clinical population genetic analysis of variants in the SARS-CoV-2 receptor ACE2Semantic proximity Read ↗

Lineage-specific positive selection on ACE2 contributes to the genetic susceptibility of COVID-19Semantic proximity Read ↗

ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2Semantic proximity Read ↗

Population history and natural selection shape patterns of genetic variation in 132 genes.Semantic proximity Read ↗

Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.