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Searching for signals of evolutionary selection in 168 genes related to immune function.

Human genetics - 1 Mar 2006

Walsh Emily C, Sabeti Pardis, Hutcheson Holli B, Fry Ben, Schaffner Stephen F, de Bakker Paul I W, Varilly Patrick, Palma Alejandro A, Roy Jessica, Cooper Richard, Winkler Cheryl, Zeng Yi, de The Guy, Lander Eric S, O'Brien Stephen, Altshuler David

Abstract excerpt

Pathogens have played a substantial role in human evolution, with past infections shaping genetic variation at loci influencing immune function. We selected 168 genes known to be involved in the immune response, genotyped common single nucleotide polymorphisms across each gene in three population samples (CEPH Europeans from Utah, Han Chinese from Guangxi, and Yoruba Nigerians from Southwest Nigeria) and searched...

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PMID: 16362345
DOI: 10.1007/s00439-005-0090-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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