Article

A computational model of CAR T-cell immunotherapy predicts leukemia patient responses at remission, resistance, and relapse

2021-09-23

Abstract excerpt

Adaptive CD19-targeted CAR (Chimeric Antigen Receptor) T-cell transfer has become a promising treatment for leukemia. Though patient responses vary across different clinical trials, there currently lacks reliable early diagnostic methods to predict patient responses to those novel therapies. Recently, computational models achieve to in silico depict patient responses, with prediction application being limited. We...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51d34088-2377-5ed5-88bb-302f96026aa4
DOI: 10.1101/2021.09.21.21263913

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A computational model of CAR T-cell immunotherapy predicts leukemia patient responses at remission, resistance, and relapseDOI 10.1101/2021.09.21.21263913Read

Individual cell-based modeling of tumor cell plasticity-induced immune escape after CAR-T therapySemantic proximity Read

Computational modelling of CAR T-cell therapy: from cellular kinetics to patient-level predictionsSemantic proximity Read

Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic LeukemiaSemantic proximity Read

Mechanisms of Resistance to CAR-T cell Immunotherapy: Insights from a Mathematical ModelSemantic proximity Read

Functional diversification and dynamics of CAR-T cells in patients with B-ALLSemantic proximity Read

Integrative AI-Enabled Virtual Cell Modeling Reveals a Clinically Relevant Latent Effector State of Human CD8⁺ T Cells Undetectable by Conventional AnalysesSemantic proximity Read

Deconvolution of clinical variance in CAR-T cell pharmacology and responseSemantic proximity Read

Modeling and Simulation of CAR T cell Therapy in Chronic Lymphocytic Leukemia PatientsSemantic proximity Read

Modeling Patient-Specific CAR-T Cell Dynamics: Multiphasic Kinetics via Phenotypic DifferentiationSemantic proximity Read

Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALLSemantic proximity Read

A bioengineered immunocompetent human leukemia chip for preclinical screening of CAR T cell immunotherapySemantic proximity Read

Analysis of causes for poor persistence of CAR-T cell therapy in vivoSemantic proximity Read