Article

Individual cell-based modeling of tumor cell plasticity-induced immune escape after CAR-T therapy

2020-06-20

Abstract excerpt

Chimeric antigen receptor (CAR) therapy targeting CD19 is an effective treatment for refractory B cell malignancies, especially B cell acute lymphoblastic leukemia (B-ALL). The majority of patients achieve a complete response following a single infusion of CD19-targeted CAR-modified T cells (CAR-19 T cells); however, many patients suffer relapse after therapy, and the underlying mechanism remains unclear. To bette...

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Literature Corpus work: 3e2b1e04-29ca-5109-88ad-4402287e610e
DOI: 10.1101/2020.06.20.163170

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