Article

Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8 + T cell repertoire upon viral exposure

2021-04-29

Abstract excerpt

Effective presentation of antigens by HLA class I molecules to CD8 + T cells is required for viral elimination and generation of long-term immunological memory. In this study, we applied a single-cell, multi-omic technology to generate the first unified ex vivo characterization of the CD8 + T cell response to SARS-CoV-2 across 4 major HLA class I alleles. We found that HLA genotype conditions key features of ep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4db99d7b-e02f-5d78-9516-eee050bab16b
DOI: 10.1101/2021.04.29.441258

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8 + T cell repertoire upon viral exposureDOI 10.1101/2021.04.29.441258Read

Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2.Semantic proximity Read

Comprehensive longitudinal profiling of SARS-CoV-2-specific CD8 + T-cells reveal strong functional impairment and recognition bias as markers for disease severitySemantic proximity Read

Distinct CD8 + T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2 + PatientsSemantic proximity Read

Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features.Semantic proximity Read

Influence of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Population and Individual Level.Semantic proximity Read

Current HLA Investigations on SARS-CoV-2 and PerspectivesSemantic proximity Read

COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2Semantic proximity Read

HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era.Semantic proximity Read

HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 eraSemantic proximity Read

Identification and characterization of an immunodominant SARS-CoV-2-specific CD8 T cell responseSemantic proximity Read

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFsSemantic proximity Read

Identification of presented SARS-CoV-2 HLA class I and HLA class II peptides using HLA peptidomicsSemantic proximity Read

Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8 <sup>+</sup> T cell repertoire upon viral exposure

Abstract excerpt

Topics

Identifiers and source

Related research