Article

Chikungunya virus persists in joint associated macrophages and promotes chronic disease

2025-06-25

Abstract excerpt

<title>Abstract</title> <p>Arthritogenic alphaviruses including chikungunya, Mayaro, and Ross River viruses cause long-lasting musculoskeletal pain and inflammation. However, mechanisms driving chronic disease remain poorly understood. Here, we investigated joint-associated tissues in alphavirus-infected mice at a late stage of infection. Utilizing scRNA-seq, spatial transcriptomics, and flow cytometry we identif...

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Literature Corpus work: 51c5cf04-311b-509e-b742-2dacb95436e4
DOI: 10.21203/rs.3.rs-6917990/v1

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