Article

Lineage-Specific Transcriptional Response to Chikungunya ECSA and West African Lineages in Primary Human Chondrocytes

2026-03-11

Abstract excerpt

Chikungunya virus (CHIKV) causes long-term arthritis in about a third of infected people. It circulates as three main lineages. The East/Central/South African (ECSA) lineage and its derivatives have led to outbreaks in the Indian Ocean, South America, Pakistan, and most recently China, while the West African (WA) lineage is restricted to West Africa. Here we characterized CHIKV lineage-specific differences in huma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c87395b2-362b-5b0c-99ba-82bb22973869
DOI: 10.64898/2026.03.10.26348026

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lineage-Specific Transcriptional Response to Chikungunya ECSA and West African Lineages in Primary Human ChondrocytesDOI 10.64898/2026.03.10.26348026Read

Single-cell transcriptomic analysis of antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblastsSemantic proximity Read

From Infection to Inflammation: A Transcriptome-Wide Analysis of CHIKV Impact on Primary Human Skeletal Muscle CellsSemantic proximity Read

Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expressionSemantic proximity Read

Chikungunya virus persists in joint associated macrophages and promotes chronic diseaseSemantic proximity Read

Early transcriptional signature in chikungunya predicts chronic arthralgia and reveals deficient antiviral responseSemantic proximity Read

Deciphering the differential response of two human fibroblast cell lines following Chikungunya virus infectionSemantic proximity Read

Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika VirusesSemantic proximity Read

Transcriptomic analysis of chronic chikungunya in the Reunionese CHIKGene cohort uncovers a shift in gene expression more than 10 years after infectionSemantic proximity Read

Transcriptomic insights into early mechanisms underlying post-chikungunya chronic inflammatory joint diseaseSemantic proximity Read

Single-Cell Transcriptomic Analysis of the Immune Response to CHIKV InfectionSemantic proximity Read

Early Immune Hypoactivation and Persistent Innate Reprogramming Characterize Chronic Chikungunya DiseaseSemantic proximity Read

Systems analysis of subjects acutely infected with the Chikungunya virusSemantic proximity Read