Article

STING deficiency-associated aberrant CXCL10 expression contributes to pathogenesis of arthritogenic alphaviruses

2020-05-15

Abstract excerpt

Arthritogenic alphaviruses such as Chikungunya virus and O’nyong nyong virus cause acute and chronic crippling arthralgia associated with inflammatory immune responses. However, the physiological functions of individual immune signaling pathways in the pathogenesis of alphaviral arthritis remain poorly understood. Here we report that a deficiency in the stimulator-of-interferon-genes (STING) led to enhanced viral...

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Identifiers and source

Literature Corpus work: 4cc33b65-d58e-5e70-9f83-e463ff90ab7b
DOI: 10.1101/2020.05.13.095083

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