Back to search

Article

Early transcriptional signature in chikungunya predicts chronic arthralgia and reveals deficient antiviral response

2026-05-05

Abstract excerpt

<h4>Objective</h4> Long-term sequelae following viral infections, such as Chikungunya and SARS-CoV-2, are associated with persistent symptoms, with a notably higher prevalence in women. This study investigated the early determinants of progression to chronic chikungunya (CC) and examined the specific role of biological sex on disease outcomes. <h4>Methods</h4> We analysed peripheral blood mononuclear cells (PBMC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8598d613-f08b-524d-aa4b-1b2cee67c9d3
DOI
10.64898/2026.05.04.26352362
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Early transcriptional signature in chikungunya predicts chronic arthralgia and reveals deficient antiviral responseDOI 10.64898/2026.05.04.26352362
Early Immune Hypoactivation and Persistent Innate Reprogramming Characterize Chronic Chikungunya DiseaseSemantic proximity
Transcriptomic analysis of chronic chikungunya in the Reunionese CHIKGene cohort uncovers a shift in gene expression more than 10 years after infectionSemantic proximity
Transcriptomic insights into early mechanisms underlying post-chikungunya chronic inflammatory joint diseaseSemantic proximity
Chikungunya Infection Increases Osteoclastogenic Genes Ex-pression in Blood and Chronic Arthralgia May Be Related to Enhanced Osteoclast SurvivalSemantic proximity
Chikungunya virus persists in joint associated macrophages and promotes chronic diseaseSemantic proximity
Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progressionSemantic proximity
Single-Cell Transcriptomic Analysis of the Immune Response to CHIKV InfectionSemantic proximity
Systems analysis of subjects acutely infected with the Chikungunya virusSemantic proximity
Lineage-Specific Transcriptional Response to Chikungunya ECSA and West African Lineages in Primary Human ChondrocytesSemantic proximity
Chikungunya virus infection in Aruba: Diagnosis, clinical features and predictors of post-chikungunya chronic polyarthralgia.Semantic proximity
Single-cell transcriptomic analysis of antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblastsSemantic proximity
From Infection to Inflammation: A Transcriptome-Wide Analysis of CHIKV Impact on Primary Human Skeletal Muscle CellsSemantic proximity
Select a neighboring publication to make it the new centre.